Selected article for: "cell viability and significant reduction"
Author: Cooray, Samantha; Jin, Li; Best, Jennifer M
Title: The involvement of survival signaling pathways in rubella-virus induced apoptosis
  • Document date: 2005_1_4
    • ID: 1i36lsj2_13
    Snippet: Cellular viability during RV infection did not appear to be disrupted, supporting previous observations which reported that a large number of monolayer cells remain in tact and do not rapidly undergo apoptosis in RV infected cells [9, 12] (Fig. 2 ). LY294002 treatment of RK13 cells reduced cell viability by 20%, which remained constant throughout the 12-96 hour period. Cell viability was reduced to 60% in the presence of both RV and LY294002. Thu.....
    Document: Cellular viability during RV infection did not appear to be disrupted, supporting previous observations which reported that a large number of monolayer cells remain in tact and do not rapidly undergo apoptosis in RV infected cells [9, 12] (Fig. 2 ). LY294002 treatment of RK13 cells reduced cell viability by 20%, which remained constant throughout the 12-96 hour period. Cell viability was reduced to 60% in the presence of both RV and LY294002. Thus the combined effect of PI3K inhibition and RV-infection caused a significant reduction in cell viability.

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