Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_42_1
Snippet: itic cell supernatants exposed to LPS inhibitor, ML29, LASV and LASV plus LPS 24 hpe. Standard deviation of THBD concentrations are shown from three different experiments. THMD from ML29 cells is significantly depressed with respect to THBD from non-exposed control cells. Lassa-exposed cells express significantly more THBD than ML29-exposed cells. doi:10.1371/journal.pntd.0002406.g004 talk between DG and a6b1 integrins, shifting the normal signal.....
Document: itic cell supernatants exposed to LPS inhibitor, ML29, LASV and LASV plus LPS 24 hpe. Standard deviation of THBD concentrations are shown from three different experiments. THMD from ML29 cells is significantly depressed with respect to THBD from non-exposed control cells. Lassa-exposed cells express significantly more THBD than ML29-exposed cells. doi:10.1371/journal.pntd.0002406.g004 talk between DG and a6b1 integrins, shifting the normal signaling equilibrium towards inhibition of the MEK/ERK pathway [67] . The DG is a ubiquitous receptor for extracellular matrix (ECM) proteins, which cooperates with b1 integrins to control cell-matrix interactions.
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