Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Document date: 2009_6_8
ID: 19noki6p_6
Snippet: Death receptors (DRs) and their ligands also play important roles in innate and adaptive immune responses by regulating cell death and survival [17] . Well-characterized death receptor ligands (DRLs) include tumor necrosis factor (TNF)-α, FasL and TNF-related apoptosis-inducing ligand (TRAIL/Apo2L). Recently, several viruses, including measles virus [18] , human immunodeficiency virus (HIV) [19] , cytomegalovirus (CMV) [20] , and herpes simplex .....
Document: Death receptors (DRs) and their ligands also play important roles in innate and adaptive immune responses by regulating cell death and survival [17] . Well-characterized death receptor ligands (DRLs) include tumor necrosis factor (TNF)-α, FasL and TNF-related apoptosis-inducing ligand (TRAIL/Apo2L). Recently, several viruses, including measles virus [18] , human immunodeficiency virus (HIV) [19] , cytomegalovirus (CMV) [20] , and herpes simplex virus (HSV) [21] , were shown to induce TRAIL expression on DCs. These "killer DCs" may be involved in the killing of virus-infected cells or bystander lymphocytes and natural killer cells. In view of the lymphopenia observed in SARS patient, we determine if DRLs expression on DCs is modulated by SARS-CoV.
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