Author: Jemielity, Stephanie; Wang, Jinyize J.; Chan, Ying Kai; Ahmed, Asim A.; Li, Wenhui; Monahan, Sheena; Bu, Xia; Farzan, Michael; Freeman, Gordon J.; Umetsu, Dale T.; DeKruyff, Rosemarie H.; Choe, Hyeryun
Title: TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine Document date: 2013_3_28
ID: 0fais1pz_2
Snippet: A recent study reported that human TIM1 (hTIM1), a protein previously implicated as a receptor for the non-enveloped hepatitis A virus [2] [3] [4] , also functioned as a receptor for the enveloped viruses Ebola (EBOV) and Marburg (MARV) [5] . This observation added hTIM1 to the long list of filovirus entry factors, which include b1-integrins [6, 7] , the folic acid receptor alpha, which was later disputed [8] [9] [10] , the TAM receptors Axl, Mer.....
Document: A recent study reported that human TIM1 (hTIM1), a protein previously implicated as a receptor for the non-enveloped hepatitis A virus [2] [3] [4] , also functioned as a receptor for the enveloped viruses Ebola (EBOV) and Marburg (MARV) [5] . This observation added hTIM1 to the long list of filovirus entry factors, which include b1-integrins [6, 7] , the folic acid receptor alpha, which was later disputed [8] [9] [10] , the TAM receptors Axl, Mer and Tyro [11] , various C-type lectins [12] [13] [14] and the intracellular receptor Niemann-Pick C1 (NPC1) [15] [16] [17] . hTIM1 was identified by correlating gene expression patterns of 60 cancer cell lines with their permissiveness to EBOV entry [5] .
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