Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Document date: 2009_6_8
ID: 19noki6p_1
Snippet: The SARS outbreak in 2003 provides a unique opportunity for the study of human response to a novel virus. The etiological agent was identified to be a coronavirus (CoV) originating from an animal reservoir [1, 2] . Clinically, patients presented with an atypical pneumonia followed by diffuse alveolar damage, with mortality up to 52% in patients over 65 years old. Interestingly, the disease pres-entations of SARS were less severe in children than .....
Document: The SARS outbreak in 2003 provides a unique opportunity for the study of human response to a novel virus. The etiological agent was identified to be a coronavirus (CoV) originating from an animal reservoir [1, 2] . Clinically, patients presented with an atypical pneumonia followed by diffuse alveolar damage, with mortality up to 52% in patients over 65 years old. Interestingly, the disease pres-entations of SARS were less severe in children than adults, and none of the infected children (< 12 years old) died of SARS [3, 4] . Evidences in the literature, including ours, support the role of immune evasion in the severity and immunopathology of SARS (Reviewed by [5] [6] [7] ), and we further suggested that the developmental status of the host immune system may be responsible for the agedependence of disease severity in SARS.
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