Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Document date: 2009_6_8
ID: 19noki6p_14
Snippet: We also assayed the expression of DRLs in SARS-CoV infected DCs as they may have an impact on the killing of bystanding immune cells. The gene expressions of FasL and TRAIL in DCs were summarised in Fig. 4 . In both adult and CB DCs, FasL gene expression was low (~0-40 copies per 10 4 β-actin) and there was a slight and insignificant induction by SARS-CoV. In the contrary, a strong induction of TRAIL gene expression was observed in SARS-CoV infe.....
Document: We also assayed the expression of DRLs in SARS-CoV infected DCs as they may have an impact on the killing of bystanding immune cells. The gene expressions of FasL and TRAIL in DCs were summarised in Fig. 4 . In both adult and CB DCs, FasL gene expression was low (~0-40 copies per 10 4 β-actin) and there was a slight and insignificant induction by SARS-CoV. In the contrary, a strong induction of TRAIL gene expression was observed in SARS-CoV infected DCs at both 3 h and 9 h post infection. The upregulated TRAIL expression in CB DCs were significantly higher than that in adult DCs (Table 1 ).
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