Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_48
Snippet: Bleeding is not a salient manifestation in most cases of LF. In contrast to South American arenaviral HF caused by JunÃn and Machupo viruses, disseminated intravascular coagulation (DIC) is rarely seen in LF patients. Nevertheless, virus-induced coagulation abnormalities and impaired vascular function is a hallmark of LF pathogenesis [3] , [86] . Platelets remain either normal or moderately low, but with significantly reduced function. Plasma fr.....
Document: Bleeding is not a salient manifestation in most cases of LF. In contrast to South American arenaviral HF caused by JunÃn and Machupo viruses, disseminated intravascular coagulation (DIC) is rarely seen in LF patients. Nevertheless, virus-induced coagulation abnormalities and impaired vascular function is a hallmark of LF pathogenesis [3] , [86] . Platelets remain either normal or moderately low, but with significantly reduced function. Plasma from LF patients has inhibitory activity on platelets from healthy individuals, suggesting the presence of soluble factors causing platelets malfunction [88] . Our previous work supports the notion that LASV can replicate vigorously in endothelial cells without cytopathic effects but with reduced cell function, such as reduced production of interleukin IL-8 [18] .
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