Author: Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.
Title: Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector Document date: 2017_2_16
ID: 09hmet7r_12
Snippet: The design of both synthetic HSV-1 amplicon vectors sWa[VP2/6/7] and sWa[VP2/6/7_V5] was based on the vector RRV[VP7/6/2] with the aim to improve transcription/translation of the transgene cassette through codon-optimization to human codon usage. Through optimization of the codon usage, the codon adaption index (CAI) increased from 0.605 to 0.895 for human and from 0.606 to 0.892 for mouse. Indeed, the codon-optimized vector sWa[VP2/6/7] induced .....
Document: The design of both synthetic HSV-1 amplicon vectors sWa[VP2/6/7] and sWa[VP2/6/7_V5] was based on the vector RRV[VP7/6/2] with the aim to improve transcription/translation of the transgene cassette through codon-optimization to human codon usage. Through optimization of the codon usage, the codon adaption index (CAI) increased from 0.605 to 0.895 for human and from 0.606 to 0.892 for mouse. Indeed, the codon-optimized vector sWa[VP2/6/7] induced an enhanced protein synthesis in human cells over the non-codon-optimized vector RRV[VP7/6/2] ( Figure 1C , left panel). This effect was not observed in the murine hepatoma cell line Hepa1-6 ( Figure 1C , right panel) even though the CAIs for the codon usage of humans and mice were very similar.
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