Author: Shapira, Assaf; Benhar, Itai
Title: Toxin-Based Therapeutic Approaches Document date: 2010_10_28
ID: 00cf294x_34
Snippet: Ovarian cancer is a common malignancy in women, and causes more deaths than any other type of female reproductive tract cancer [379] . Lidor et al [342] have demonstrated specific protein synthesis inhibition in malignant ovarian cell lines transfected with plasmids encoding transcriptionally regulated diphtheria DT-A. The toxic gene transcription was regulated by elements of the human chorionic gonadotropin (hCG) promoter, a heterodimeric glycop.....
Document: Ovarian cancer is a common malignancy in women, and causes more deaths than any other type of female reproductive tract cancer [379] . Lidor et al [342] have demonstrated specific protein synthesis inhibition in malignant ovarian cell lines transfected with plasmids encoding transcriptionally regulated diphtheria DT-A. The toxic gene transcription was regulated by elements of the human chorionic gonadotropin (hCG) promoter, a heterodimeric glycoprotein placental hormone involved in different pregnancy-promoting processes. Although principally produced by trophoblasts, hCG is also expressed in some malignant tumors of the ovary, uterus, testis, colon, liver, pancreas lung, and stomach [380] [381] [382] .
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