Author: Shapira, Assaf; Benhar, Itai
Title: Toxin-Based Therapeutic Approaches Document date: 2010_10_28
ID: 00cf294x_49
Snippet: Treatment with PA-L1/LF also delayed tumor growth and improved long-term survival in mice with orthotopically implanted anaplastic thyroid carcinoma (ATC) xenografts. The antitumorogenic effect was comparable with that achieved by the multikinase inhibitor, sorafenib, which is currently under evaluation for clinical use in patients with papillary thyroid carcinoma (PTC). As was already found in previous studies [422, 423] , the therapeutic effect.....
Document: Treatment with PA-L1/LF also delayed tumor growth and improved long-term survival in mice with orthotopically implanted anaplastic thyroid carcinoma (ATC) xenografts. The antitumorogenic effect was comparable with that achieved by the multikinase inhibitor, sorafenib, which is currently under evaluation for clinical use in patients with papillary thyroid carcinoma (PTC). As was already found in previous studies [422, 423] , the therapeutic effect of PA-L1/LF was mediated by the potent antiangiogenic activity of the drug, which did not cause any significant systemic toxicity [424] .
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