Author: Shapira, Assaf; Benhar, Itai
Title: Toxin-Based Therapeutic Approaches Document date: 2010_10_28
ID: 00cf294x_59
Snippet: In a comprehensive study by Falnes et al [512] , the in vivo stability and cytotoxicity of diphtheria toxin-based polypeptides, artificially modified to initiate with short sequences derived from the FLAG peptide epitope differing only in their N-terminal amino acids, were assessed. According to their findings, when the first N terminal amino acid of the modified toxins were Phe, Tyr, Trp, Asp, Asn, Glu, Gln, Lys, Arg or His, the proteins were hi.....
Document: In a comprehensive study by Falnes et al [512] , the in vivo stability and cytotoxicity of diphtheria toxin-based polypeptides, artificially modified to initiate with short sequences derived from the FLAG peptide epitope differing only in their N-terminal amino acids, were assessed. According to their findings, when the first N terminal amino acid of the modified toxins were Phe, Tyr, Trp, Asp, Asn, Glu, Gln, Lys, Arg or His, the proteins were highly unstable, with half-lives in the range 0.2-1.6 hours, while the toxins initiated with either of the remaining amino acids were considerably more stable, with half-lives ranging from 3 to >12 hours.
Search related documents:
Co phrase search for related documents- amino acid and FLAG peptide: 1, 2
- amino acid and half life: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- amino acid and range life: 1, 2
- amino acid and remain amino acid: 1, 2
- amino acid and short sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- comprehensive study and half life: 1
- cytotoxicity vivo stability and half life: 1, 2
- half life and range life: 1, 2, 3, 4, 5, 6, 7, 8
- half range life and range life: 1, 2, 3, 4, 5, 6, 7, 8
Co phrase search for related documents, hyperlinks ordered by date