Author: van Rijn, Anneloes L.; van Boheemen, Sander; Sidorov, Igor; Carbo, Ellen C.; Pappas, Nikos; Mei, Hailiang; Feltkamp, Mariet; Aanerud, Marianne; Bakke, Per; Claas, Eric C. J.; Eagan, Tomas M.; Hiemstra, Pieter S.; Kroes, Aloys C. M.; de Vries, Jutte J. C.
Title: The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease Document date: 2019_10_24
ID: 0rupk21u_50
Snippet: In this study, the respiratory virome in patients with COPD exacerbations was analysed with both mNGS and qPCR, and combined with clinical data. The incidence of viral pathogens was 26% with both mNGS and qPCR. mNGS failed to detect one Rhinovirus with low load (Cq 38) and PCR failed to detect one betacoronavirus OC43 (72644 reads), due to one of the limitations of PCR, i.e. inhibition of amplification. One additional viral pathogen, not present .....
Document: In this study, the respiratory virome in patients with COPD exacerbations was analysed with both mNGS and qPCR, and combined with clinical data. The incidence of viral pathogens was 26% with both mNGS and qPCR. mNGS failed to detect one Rhinovirus with low load (Cq 38) and PCR failed to detect one betacoronavirus OC43 (72644 reads), due to one of the limitations of PCR, i.e. inhibition of amplification. One additional viral pathogen, not present in the respiratory PCR panel, was detected: herpes simplex virus 1, found by others to be associated with COPD [27] .
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