Selected article for: "entry pathway and IAV entry pathway"
Author: de Vries, Erik; Tscherne, Donna M.; Wienholts, Marleen J.; Cobos-Jiménez, Viviana; Scholte, Florine; García-Sastre, Adolfo; Rottier, Peter J. M.; de Haan, Cornelis A. M.
Title: Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway
  • Document date: 2011_3_31
    • ID: 05lnj3w0_30
    Snippet: The data presented in this study demonstrate for the first time that IAV can enter cells via DYNA-IND macropinocytosis in addition to the previously described DYNA-DEP classical CME pathway [1, 2] . Several lines of evidence indicate that the DYNA-IND entry route of IAV that we identified corresponds with macropinocytosis. First of all, the entry pathway is dependent on the presence of serum, a well-known inducer of macropinocytosis. Second, IAV .....
    Document: The data presented in this study demonstrate for the first time that IAV can enter cells via DYNA-IND macropinocytosis in addition to the previously described DYNA-DEP classical CME pathway [1, 2] . Several lines of evidence indicate that the DYNA-IND entry route of IAV that we identified corresponds with macropinocytosis. First of all, the entry pathway is dependent on the presence of serum, a well-known inducer of macropinocytosis. Second, IAV colocalized in vesicles with soluble FITC-dextran, a marker for macropinocytosis. Third, DYNA-IND IAV entry was sensitive to the amiloride-derivative EIPA, the hallmark inhibitor of macropinocytosis [14, [55] [56] [57] [58] . Fourth, this IAV entry pathway is sensitive to inhibitors or dominant-negative mutants affecting actomyosin dynamics. Fifth, the specific inhibition of DYNA-IND IAV entry by a number of inhibitors of growth factor receptor tyrosine kinases as well as downstream effectors thereof also points at the involvement of macropinocytosis. Finally, macropinocytosis is independent of dynamin [12, 14, 19] .

    Search related documents:
    Co phrase search for related documents
    • cell enter and entry pathway: 1, 2, 3, 4
    • cell enter and entry route: 1, 2
    • cell enter and growth factor: 1, 2
    • cell enter and growth factor receptor: 1
    • classical cme and DYNA ind: 1
    • classical cme and DYNA IND IAV entry: 1
    • classical cme and DYNA ind IAV entry route: 1
    • classical cme and entry pathway: 1, 2
    • classical cme and entry route: 1, 2
    • classical cme pathway and DYNA ind: 1
    • classical cme pathway and DYNA IND IAV entry: 1
    • classical cme pathway and DYNA ind IAV entry route: 1
    • classical cme pathway and entry pathway: 1
    • classical cme pathway and entry route: 1
    • dominant negative mutant and DYNA ind: 1
    • dominant negative mutant and DYNA IND IAV entry: 1
    • dominant negative mutant and entry pathway: 1, 2, 3
    • downstream effector and growth factor: 1, 2
    • downstream effector and growth factor receptor: 1