Selected article for: "absence presence and cell addition"
Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
  • Document date: 2019_12_25
    • ID: 034w5afv_11
    Snippet: A total of eight candidate polymers were evaluated to test their ability to maintain NTZ solubilized: Methocel ® MC, Methocel ® 60 HG, HPMC, HPC 80,000, HPC 370,000, Kollisolv ® , Kolliphor ® P 407, and Kollidon ® 25 (see Table S1 , for further polymer details). The tests were performed by the modified solvent shift method proposed by Childs et al. in 2013 [24] , see Figure S1 . Aqueous solutions were prepared containing 0.5% w/v of each pre.....
    Document: A total of eight candidate polymers were evaluated to test their ability to maintain NTZ solubilized: Methocel ® MC, Methocel ® 60 HG, HPMC, HPC 80,000, HPC 370,000, Kollisolv ® , Kolliphor ® P 407, and Kollidon ® 25 (see Table S1 , for further polymer details). The tests were performed by the modified solvent shift method proposed by Childs et al. in 2013 [24] , see Figure S1 . Aqueous solutions were prepared containing 0.5% w/v of each pre-dissolved polymer in pH 7.5 phosphate buffer solution (PBS) Pharmaceutics 2020, 12, 23 4 of 18 and also one containing only buffer solution. A volume of 3 mL of each medium was placed in a spectrophotometer quartz cell, followed by a stepwise addition of a total of 13 aliquots of 10 µL each from NTZ stock solution in DMSO (25 mg/mL) at 5 min interval times. The ability of the polymeric compounds to maintain the API dissolved was determined by analysis of the presence or absence of precipitated NTZ in solution, which can be monitored by UV-vis spectrophotometry measured at λ = 550 nm.

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