Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea

Due to this former behavior, cocrystals are potential candidates for the development of supersaturating drug delivery systems [20, 21] . A strategy to control cocrystal dissolution, drug supersaturation and precipitation is the use of supersaturated formulations, which incorporates additives and excipients such as cyclodextrins, surfactants and polymers [22] . In such systems, the supersaturation state must be maintained over a reasonable time period in order to promote adequate absorption for increased bioavailability. In this line, there are several recent reports on the effect of polymers and surfactants in increasing solubility and dissolution rates of poorly soluble drugs, starting from a cocrystalline solid phase. Some representative APIs and nutraceutical compounds studied under this approach are celecoxib [23] , danazol [24] , indomethacin [25] , carbamazepine [26] [27] [28] [29] [30] [31] , flufenamic acid [32] , cilostazol [33] , resveratrol [34] , dihydromyricetin [35] , tadalafil [36] , exemestane [37] and posaconazole [38] .