Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers Document date: 2019_12_25
ID: 034w5afv_50
Snippet: Cellulosic polymers are the most common hydrophilic polymers used for the development of formulations with cocrystals [24, 26, 28, 29, 33, 36, 37] . They can inhibit or at least delay phase transformations of cocrystals [29, 30] , by establishing drug-polymer interactions [37] and maintaining the solubilization state of APIs. Therefore, the improvement of the NTZ dissolution profiles in the presence of pre-dissolved polymer could be explained by .....
Document: Cellulosic polymers are the most common hydrophilic polymers used for the development of formulations with cocrystals [24, 26, 28, 29, 33, 36, 37] . They can inhibit or at least delay phase transformations of cocrystals [29, 30] , by establishing drug-polymer interactions [37] and maintaining the solubilization state of APIs. Therefore, the improvement of the NTZ dissolution profiles in the presence of pre-dissolved polymer could be explained by the following mechanism: after the rapid NTZ release into solution starting from the cocrystal, the cellulosic polymer interacts with NTZ molecules delaying its nucleation and eventually NTZ crystallized also interact with polymer interfering the crystal growth and agglomeration process.
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