Author: Gupta, Neha; Richter, Robert; Robert, Stephen; Kong, Michele
Title: Viral Sepsis in Children Document date: 2018_9_18
ID: 050vjj6k_39
Snippet: Seasonal influenza epidemics and various pandemics have historically led to significant morbidity and mortality in the past, either due to exacerbation of an underlying condition or due to secondary bacterial infections. Mortality with influenza varies not only with season, but with predominant influenza strain and effectiveness of influenza vaccine each season. During the first year of the pandemic 2009 H1N1, global mortality in children aged 0-.....
Document: Seasonal influenza epidemics and various pandemics have historically led to significant morbidity and mortality in the past, either due to exacerbation of an underlying condition or due to secondary bacterial infections. Mortality with influenza varies not only with season, but with predominant influenza strain and effectiveness of influenza vaccine each season. During the first year of the pandemic 2009 H1N1, global mortality in children aged 0-17 years was estimated to be as high as ∼ 45,000 cases, with majority of deaths occurring in Southeast Asia and Africa (175) . Both pediatric and adult patients during this pandemic had a very rapid progression to respiratory failure and required prolonged mechanical ventilation and vasopressor support (176, 177) . Various extrapulmonary complications secondary to influenza sepsis have been reported in the literature. These include, but are not limited to renal failure, rhabdomyolysis, encephalopathy, myocarditis, and multiorgan failure. These complications also lead to poorer outcomes (178) .
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