Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_45
Snippet: As would be expected from PBMC exposure to other RNA viruses, transcriptome analysis showed that the set of IFNstimulated genes (ISG) is the most affected after exposure to LASV or ML29. The antiviral-ISG, including GBP1, IFI44, IFIH1, IFIT1, MX1, and LY6E, were the most common group of up-regulated genes after influenza infection [69] , yellow fever vaccination [70] , and during febrile episodes of dengue hemorrhagic fever [71] , [72] ......
Document: As would be expected from PBMC exposure to other RNA viruses, transcriptome analysis showed that the set of IFNstimulated genes (ISG) is the most affected after exposure to LASV or ML29. The antiviral-ISG, including GBP1, IFI44, IFIH1, IFIT1, MX1, and LY6E, were the most common group of up-regulated genes after influenza infection [69] , yellow fever vaccination [70] , and during febrile episodes of dengue hemorrhagic fever [71] , [72] .
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