Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_47
Snippet: LASV up-regulates CXCL6, an IL-8 homolog, as well as three other genes that control cell trafficking: monocyte-attracting chemokines CCL7 [81] and CCL8 (or monocyte chemotactic protein-2, MCP-2 [82] [83] , and the mannose receptor C type 1 (MRC1) [84] . These in vitro responses may be related to clinical observations of higher serum IL-8 levels in patients with acute non-fatal LF than in control subjects. Levels of IL-8 and other proinflammatory .....
Document: LASV up-regulates CXCL6, an IL-8 homolog, as well as three other genes that control cell trafficking: monocyte-attracting chemokines CCL7 [81] and CCL8 (or monocyte chemotactic protein-2, MCP-2 [82] [83] , and the mannose receptor C type 1 (MRC1) [84] . These in vitro responses may be related to clinical observations of higher serum IL-8 levels in patients with acute non-fatal LF than in control subjects. Levels of IL-8 and other proinflammatory cyto/chemokines (IL-1b, IL-6, IL-10, IP-10, TNFa) were low or undetectable in patients with fatal LF [21] supporting our previous observations in primary human cells [18] . These observations were also confirmed in animal models of fatal LF [20] , [17] , [85] , [30] providing no evidence for the type of ''cytokine storm'' observed in filovirus HF [86] , [87] . The idea that an uncontrolled replication of LASV in targets cells, DC and macrophages, is associated with a marked suppression of innate and adaptive immune responses resulting in clinical progression and death of experimental animals and LF patients is a wellaccepted concept.
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