Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_53
Snippet: In LASV-infected primates, DC and macrophages were identified as prominent targets at early stages of infection, while Kupffer cells, hepatocytes, adrenal cortical cells, and endothelial cells were more frequently infected at late stages [99] . We showed previously that mononuclear cells in PBMC are not permissive for LASV and the virus can replicate only in differentiated monocytes, DC and macrophages [18] , representing less than 1% of circulat.....
Document: In LASV-infected primates, DC and macrophages were identified as prominent targets at early stages of infection, while Kupffer cells, hepatocytes, adrenal cortical cells, and endothelial cells were more frequently infected at late stages [99] . We showed previously that mononuclear cells in PBMC are not permissive for LASV and the virus can replicate only in differentiated monocytes, DC and macrophages [18] , representing less than 1% of circulating PBMC. Since LASV and ML29 replicate at the same rate in monocyte-derived cultures (ISL unpublished), the differential gene expression reported here is most likely due to differential signaling of uninfected bystander cells.
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