Author: Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.
Title: Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector Document date: 2017_2_16
ID: 09hmet7r_6
Snippet: Structural vaccinology approaches involve the engineering of immunogens using a combination of structural biology and immunology with the idea that the protective antigens are optimized and simplified for inclusion in vaccine formulations to enhance efficacy, stability and delivery to obtain a stronger immunogenicity and hence a broader protection. An important goal of structural vaccinology is the conformational stabilization of an antigen based.....
Document: Structural vaccinology approaches involve the engineering of immunogens using a combination of structural biology and immunology with the idea that the protective antigens are optimized and simplified for inclusion in vaccine formulations to enhance efficacy, stability and delivery to obtain a stronger immunogenicity and hence a broader protection. An important goal of structural vaccinology is the conformational stabilization of an antigen based on its native three-dimensional structure to induce an efficacious immune response. Based on these principles, we aimed to increase the amounts of VLP-generating and immunizing proteins synthesized in situ, we chose to alter the sequence of viral genes in the amplicon vector and optimized the amino acid sequence to the codon usage of human cells.
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