Selected article for: "envelope protein and positive sense"
Author: Qian, Shaoju; Gao, Zitong; Cao, Rui; Yang, Kang; Cui, Yijie; Li, Shaowen; Meng, Xianrong; He, Qigai; Li, Zili
Title: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-ß in Porcine Intestinal Epithelial Cells
  • Document date: 2020_1_21
    • ID: 06qddkw0_1
    Snippet: Transmissible gastroenteritis virus (TGEV) infection mainly causes severe watery diarrhea, vomiting, dehydration, and mortality in suckling piglets less than 2 weeks old, as well as colossal economic losses in the worldwide pig industry (Zhao et al., 2014) . TGEV has a 28.5-kb singlestranded, positive-sense RNA genome, including at least nine open reading frames (ORFs): ORF1a, ORF1b, Structural proteins, nucleocapsid (N) protein, membrane (M) gly.....
    Document: Transmissible gastroenteritis virus (TGEV) infection mainly causes severe watery diarrhea, vomiting, dehydration, and mortality in suckling piglets less than 2 weeks old, as well as colossal economic losses in the worldwide pig industry (Zhao et al., 2014) . TGEV has a 28.5-kb singlestranded, positive-sense RNA genome, including at least nine open reading frames (ORFs): ORF1a, ORF1b, Structural proteins, nucleocapsid (N) protein, membrane (M) glycoprotein, spike (S) glycoprotein, a small envelope (E) glycoprotein, and accessory proteins 3a, 3b, and 7 (Escors et al., 2003) . ORF1a and ORF1b, located in the 5 twothirds of the viral genome, are cleaved into 16 non-structural proteins (nsp1 to nsp16) by the nsp3 and nsp5 proteases. These nsps are responsible for viral replication, viral transcription, and the antagonization of host innate immune responses.

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