Author: Qian, Shaoju; Gao, Zitong; Cao, Rui; Yang, Kang; Cui, Yijie; Li, Shaowen; Meng, Xianrong; He, Qigai; Li, Zili
Title: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-ß in Porcine Intestinal Epithelial Cells Document date: 2020_1_21
ID: 06qddkw0_19
Snippet: To examine if TGEV infection induces FcRn promoter activation, IPEC-J2 cells were co-transfected with FcRn-luc or pRL-TK. Twenty-four hours later, the cells were incubated with live or UVinactivated TGEV for 12, 24, 36, and 48 h post-infection (hpi). Enhanced FcRn luciferase activities tended to increase during the progression of TGEV infection from 24 to 48 hpi, and this increase was significantly different compared with mock-infected IPEC-J2 ce.....
Document: To examine if TGEV infection induces FcRn promoter activation, IPEC-J2 cells were co-transfected with FcRn-luc or pRL-TK. Twenty-four hours later, the cells were incubated with live or UVinactivated TGEV for 12, 24, 36, and 48 h post-infection (hpi). Enhanced FcRn luciferase activities tended to increase during the progression of TGEV infection from 24 to 48 hpi, and this increase was significantly different compared with mock-infected IPEC-J2 cells ( Figure 1A) . Therefore, the up-regulation of FcRn is closely related to the replication of TGEV.
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