Author: Qian, Shaoju; Gao, Zitong; Cao, Rui; Yang, Kang; Cui, Yijie; Li, Shaowen; Meng, Xianrong; He, Qigai; Li, Zili
Title: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-ß in Porcine Intestinal Epithelial Cells Document date: 2020_1_21
ID: 06qddkw0_26
Snippet: We treated IPEC-J2 cells with TNF-α and IL-1β in different concentrations. TNF-α and IL-1β induced FcRn expression in a dose-dependent manner, increasing mRNA levels 1.5-1.7-fold after 2 h (Figures 3C,D) . Interestingly, we found that TGF-β can also up-regulate FcRn, increasing the mRNA level 1.9-fold after 2 h ( Figure 3E) . Meanwhile, IPEC-J2 cells were treated with SB202190 (p38 inhibitor), SP600125 (JNK1/2 inhibitor) and U0126 (ERK1/2 in.....
Document: We treated IPEC-J2 cells with TNF-α and IL-1β in different concentrations. TNF-α and IL-1β induced FcRn expression in a dose-dependent manner, increasing mRNA levels 1.5-1.7-fold after 2 h (Figures 3C,D) . Interestingly, we found that TGF-β can also up-regulate FcRn, increasing the mRNA level 1.9-fold after 2 h ( Figure 3E) . Meanwhile, IPEC-J2 cells were treated with SB202190 (p38 inhibitor), SP600125 (JNK1/2 inhibitor) and U0126 (ERK1/2 inhibitor), followed by TGF-β incubation. Treatment with SP600125 sharply reduced FcRn expression, indicating that TGF-β up-regulated FcRn expressions via the c-Jun amino-terminal kinase (JNK)-MAPK pathway in IPEC-J2 cells ( Figure 3F ).
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