Selected article for: "humoral cellular response and immune response"
Author: Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.
Title: Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector
  • Document date: 2017_2_16
    • ID: 09hmet7r_3
    Snippet: Virus-like-particles (VLPs) are composed of one or several viral capsid proteins that self-assemble into a spatial conformation that resembles the structure of the original virus. Virus-like-particles comprise a high density of epitopes on their surface, which can be recognized by antigen presenting cells (APCs) and thereby stimulate a humoral and cellular immune response through similar pathways as the complete, pathogenic virus [7] . Virus-like.....
    Document: Virus-like-particles (VLPs) are composed of one or several viral capsid proteins that self-assemble into a spatial conformation that resembles the structure of the original virus. Virus-like-particles comprise a high density of epitopes on their surface, which can be recognized by antigen presenting cells (APCs) and thereby stimulate a humoral and cellular immune response through similar pathways as the complete, pathogenic virus [7] . Virus-like-particles do not contain any genetic material and thus do not replicate and are therefore considered safe. Vaccines based on purified VLPs, for example Gardasil (Merck and Co., Inc., Whitehouse Station, NJ, USA) and Cervarix (GlaxoSmithKline, Inc., Brentford, UK) for human papilloma virus (HPV) immunization and Recombivax HB against hepatitis B virus (HBV; Merck and Co., Inc., Whitehouse Station, NJ, USA), are on the market [8] .

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