Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_3
Snippet: Mitophagy is a special selective type of autophagy that is essential for maintaining balanced mitochondrial dynamics by clearing dysfunctional or damaged mitochondria (Kim et al., 2007) . Mitophagy has emerged as a regulatory mechanism that controls the antiviral innate immune response against intracellular pathogens (Deretic and Levine, 2009) . Many studies have shown that mitochondrial dynamics play important roles in the interaction of molecul.....
Document: Mitophagy is a special selective type of autophagy that is essential for maintaining balanced mitochondrial dynamics by clearing dysfunctional or damaged mitochondria (Kim et al., 2007) . Mitophagy has emerged as a regulatory mechanism that controls the antiviral innate immune response against intracellular pathogens (Deretic and Levine, 2009) . Many studies have shown that mitochondrial dynamics play important roles in the interaction of molecules, such as mitochondrial antiviral signaling protein, in the downstream signaling of interferon (IFN) synthesis (Castanier et al., 2010) . Evidence suggests that some antibiotics, including DOX, may negatively affect the immune response (Glette et al., 1984; Bellahsene and Forsgren, 1985; Woo et al., 1999) .
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