Author: Romagosa, Anna; Allerson, Matt; Gramer, Marie; Joo, Han Soo; Deen, John; Detmer, Susan; Torremorell, Montserrat
Title: Vaccination of influenza a virus decreases transmission rates in pigs Document date: 2011_12_20
ID: 0q8fedqf_78
Snippet: Overall, an important consideration in regards to inactivated vaccines is whether viruses can replicate and transmit in the presence of some degree of immunity. Under those conditions, virus escape variants can arise and can lead to antigenic drift, loss of vaccine efficacy, and emergence of new strains. Subclinical infections with virus shedding can occur in vaccinated animals, particularly when there is a mismatch between the vaccine and field .....
Document: Overall, an important consideration in regards to inactivated vaccines is whether viruses can replicate and transmit in the presence of some degree of immunity. Under those conditions, virus escape variants can arise and can lead to antigenic drift, loss of vaccine efficacy, and emergence of new strains. Subclinical infections with virus shedding can occur in vaccinated animals, particularly when there is a mismatch between the vaccine and field virus strains [12, 53] . In our study, virus replication and transmission was observed in the HE vaccinated group which suggest the potential role of vaccination in the establishment of enzootic infections and predisposition to virus change. However, whether virus changes happened as a result of vaccine immune pressure it is beyond the scope of this study and warrants future studies.
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