Author: Crane, Meredith J.; Gaddi, Pamela J.; Salazar-Mather, Thais P.
Title: UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection Document date: 2012_6_18
ID: 0vsf67nh_21
Snippet: Despite impairments in liver IFN-a production in 3d mice, it is notable that this response was not totally abrogated. This suggests the presence of alternative pathways to type I IFN production in the liver, and may be the reason that IFNa/bR-deficient mice die by day 5 in response to infection with a moderate dose of MCMV, as reported previously [36] , while 3d mice do not. Studies have also demonstrated production of type I interferon from cell.....
Document: Despite impairments in liver IFN-a production in 3d mice, it is notable that this response was not totally abrogated. This suggests the presence of alternative pathways to type I IFN production in the liver, and may be the reason that IFNa/bR-deficient mice die by day 5 in response to infection with a moderate dose of MCMV, as reported previously [36] , while 3d mice do not. Studies have also demonstrated production of type I interferon from cells other than pDCs at 44-48 hours following MCMV infection [32, 48, 49] . In addition, the liver contains a variety of parenchymal and nonparenchymal cells that express TLRs and are capable of type I IFN production [38, [40] [41] [42] . There may also be TLR-independent pathways leading to the production of these cytokines in response to MCMV, including cytoplasmic RNA-and DNA-sensing receptors, as have been demonstrated with other virus models but have yet to be examined in the context of MCMV infection [1] [2] [3] [4] [50] [51] [52] [53] [54] [55] .
Search related documents:
Co phrase search for related documents- alternative pathway and ifn production: 1, 2
- alternative pathway and virus model: 1
- cytokine production and ifn production: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cytokine production and liver ifn production: 1, 2, 3, 4
- cytokine production and mcmv infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cytokine production and MCMV moderate dose: 1, 2
- cytokine production and MCMV moderate dose infection: 1
- cytokine production and MCMV response: 1, 2, 3, 4, 5, 6, 7, 8
- cytokine production and moderate dose: 1, 2
- cytokine production and pdcs cell: 1, 2
- cytokine production and tlr express: 1
- cytokine production and virus model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cytokine production lead and ifn production: 1, 2
Co phrase search for related documents, hyperlinks ordered by date