Author: Wang, Ting; Yin, Huiquan; Li, Yan; Zhao, Lingxiao; Sun, Xiahui; Cong, Hua
Title: Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes Document date: 2017_4_3
ID: 1ay8y7li_45
Snippet: Earlier studies [14, 26, 34] have determined mortality, cytokine production, and parasite burden after challenge infection in susceptible and resistant strains of mice with the same or similar doses of T. gondii parasites. These studies found that different inbred strains of mice have markedly different susceptibility to T. gondii infection. These susceptibility differences may be due to differences in the virulence of the parasite itself or diff.....
Document: Earlier studies [14, 26, 34] have determined mortality, cytokine production, and parasite burden after challenge infection in susceptible and resistant strains of mice with the same or similar doses of T. gondii parasites. These studies found that different inbred strains of mice have markedly different susceptibility to T. gondii infection. These susceptibility differences may be due to differences in the virulence of the parasite itself or differences in the genetic make-up of the mice in terms of their immune response. In our study, only one inbred strain of mice was used for the experiment. It is therefore necessary to assess the different immunizations in different strains of mice in future research.
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