Selected article for: "competition binding and SARS bind"
Author: M. Gordon Joyce; Rajeshwer S. Sankhala; Wei-Hung Chen; Misook Choe; Hongjun Bai; Agnes Hajduczki; Lianying Yan; Spencer L. Sterling; Caroline E. Peterson; Ethan C. Green; Clayton Smith; Natalia de Val; Mihret Amare; Paul Scott; Eric D. Laing; Christopher C. Broder; Morgane Rolland; Nelson L. Michael; Kayvon Modjarrad
Title: A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein
  • Document date: 2020_3_17
    • ID: ebbzx8yr_5
    Snippet: In an effort to identify antibodies that could bind to SARS-CoV-2, we screened a set of SARS-CoV, (Tripp et al., 2005) and MERS CoV (Wang et al., 2018; Wang et al., 2015) RBD-reactive antibodies for binding to the SARS-CoV-2 RBD. We demonstrated that the SARS-CoV mouse antibody 240CD (Tripp et al., 2005) had nanomolar (nM) affinity for the SARS-CoV-2 RBD and did not significantly block ACE-2 receptor binding (Figure 2 ). CR3022-a SARS-CoV neutral.....
    Document: In an effort to identify antibodies that could bind to SARS-CoV-2, we screened a set of SARS-CoV, (Tripp et al., 2005) and MERS CoV (Wang et al., 2018; Wang et al., 2015) RBD-reactive antibodies for binding to the SARS-CoV-2 RBD. We demonstrated that the SARS-CoV mouse antibody 240CD (Tripp et al., 2005) had nanomolar (nM) affinity for the SARS-CoV-2 RBD and did not significantly block ACE-2 receptor binding (Figure 2 ). CR3022-a SARS-CoV neutralizing antibody (Tian et al., 2020) identified from a human phage-display library (ter Meulen et al., 2006) -also bound to SARS-CoV-2 RBD with nM affinity ( Figure 2B) . We assessed competition binding between 240CD and CR3022, and show that these antibodies cross-compete with each other for binding to the SARS-CoV-2 RBD (Figure 2C, 2D) .

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