Author: Romagosa, Anna; Allerson, Matt; Gramer, Marie; Joo, Han Soo; Deen, John; Detmer, Susan; Torremorell, Montserrat
Title: Vaccination of influenza a virus decreases transmission rates in pigs Document date: 2011_12_20
ID: 0q8fedqf_4
Snippet: The reproduction ratio has been assessed for influenza A virus in humans, birds, and horses [28] [29] [30] [31] [32] [33] , but R has not been reported for influenza virus A in pigs. In this study, a deterministic SIR model (Susceptible-Infected-Recovered/Removed) was used to compare transmission parameters between a non-vaccinated population and vaccinated populations of pigs following the introduction of a non-vaccinated, infected pig with a tr.....
Document: The reproduction ratio has been assessed for influenza A virus in humans, birds, and horses [28] [29] [30] [31] [32] [33] , but R has not been reported for influenza virus A in pigs. In this study, a deterministic SIR model (Susceptible-Infected-Recovered/Removed) was used to compare transmission parameters between a non-vaccinated population and vaccinated populations of pigs following the introduction of a non-vaccinated, infected pig with a triple reassortant H1N1 influenza A virus. The introduction of infected pigs into populations is one of the primary modes of influenza virus transmission in field settings and this study mimics a similar scenario. Specifically we aimed at assessing the effect of vaccination on pig susceptibility to infection. Since different vaccines containing inactivated viruses that were either homologous or heterologous to the challenge virus were used in this study, an additional comparison could be made between vaccine types. Results from this study provide relevant information on the use of vaccination to control influenza transmission, and highlight the implications of partial protection may have in transmission dynamics and risk of infection.
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