Widespread Divergence of the CEACAM/PSG Genes in Vertebrates and Humans Suggests Sensitivity to Selection

Chang, Chia Lin; Semyonov, Jenia; Cheng, Po Jen; Huang, Shang Yu; Park, Jae Il; Tsai, Huai-Jen; Lin, Cheng-Yung; Grützner, Frank; Soong, Yung Kuei; Cai, James J.; Hsu, Sheau Yu Teddy

In addition, analysis of linkage disequilibrium (LD) at the CEACAM/PSG locus among HapMap II populations indicated that CEACAM7-5-6, PSG11-2-5-4, and CEACAM21-4 regions exhibit long-range LD patterns. Importantly, LD patterns in these regions are population specific. In the CEACAM7-5-6 region, extensive LD was obvious only in CEU and ASN, but not YRI populations (Fig. S6a in File S1). At the PSG11-2-5-4 region, a unique pattern of LD was only shared by CEU and YRI populations (Fig. S6b in File S1). On the other hand, extensive LD at the CEACAM21-4 region was only found in ASN populations (Fig. S6c in File S1).