Author: Sze, Ching Wooen; Tan, Yee-Joo
Title: Viral Membrane Channels: Role and Function in the Virus Life Cycle Document date: 2015_6_23
ID: 0gkonrzw_9
Snippet: IAV can perturb the trans-Golgi network (TGN) using its M2 viroporin to affect the secretory pathway in the host. In addition to its role in virus uncoating, the ion channel activity of M2 is required for the trafficking and processing of viral proteins, such as the HA glycoprotein [11] as well as M2 itself. Expression of M2 delayed its presentation at the cell surface, which could be prevented using a viroporin inhibitor, amantadine. Using its p.....
Document: IAV can perturb the trans-Golgi network (TGN) using its M2 viroporin to affect the secretory pathway in the host. In addition to its role in virus uncoating, the ion channel activity of M2 is required for the trafficking and processing of viral proteins, such as the HA glycoprotein [11] as well as M2 itself. Expression of M2 delayed its presentation at the cell surface, which could be prevented using a viroporin inhibitor, amantadine. Using its proton channel activity, M2 prevents the acidification of the trans-Golgi, resulting in delay of protein trafficking through the TGN [12] . By doing so, M2 helps to coordinate the presentation and maturation of the viral glycoprotein on the membrane with viral assembly [12] [13] [14] .
Search related documents:
Co phrase search for related documents- cell surface and HA glycoprotein: 1, 2, 3, 4, 5, 6, 7
- cell surface and ion channel: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell surface and ion channel activity: 1, 2, 3, 4
- cell surface and maturation presentation: 1
- cell surface and processing trafficking: 1, 2, 3, 4
- cell surface and proton channel: 1, 2
- cell surface and secretory pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- cell surface and TGN traffic: 1, 2
- cell surface and TGN trans Golgi network: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell surface and trans Golgi network: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- cell surface and viral assembly: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cell surface and viral glycoprotein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60
- cell surface and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- cell surface and viral protein processing trafficking: 1
- cell surface and virus uncoating: 1, 2, 3, 4, 5, 6
- HA glycoprotein and ion channel: 1, 2, 3
- HA glycoprotein and ion channel activity: 1
- HA glycoprotein and processing trafficking: 1
- HA glycoprotein and proton channel: 1, 2
Co phrase search for related documents, hyperlinks ordered by date