Selected article for: "coding region and gene order"
Author: Wang, Shiliang; Sundaram, Jaideep P; Spiro, David
Title: VIGOR, an annotation program for small viral genomes
  • Document date: 2010_9_7
    • ID: 0lbxvudt_31
    Snippet: The influenza virus genome consists of eight RNA segments that encode one or two proteins each. Splicing is involved in the expression of the MP and M2 proteins from segment 7 (MP segment) in group A influenza viruses and NS1 and NS2 proteins from segment 8 (NS segment) in both group A and group B viruses [16] . Segment 2 (PB1 segment) encodes two proteins, PB1 and PB1-F2, in some influenza genomes. The coding sequence of PB1-F2 is completely emb.....
    Document: The influenza virus genome consists of eight RNA segments that encode one or two proteins each. Splicing is involved in the expression of the MP and M2 proteins from segment 7 (MP segment) in group A influenza viruses and NS1 and NS2 proteins from segment 8 (NS segment) in both group A and group B viruses [16] . Segment 2 (PB1 segment) encodes two proteins, PB1 and PB1-F2, in some influenza genomes. The coding sequence of PB1-F2 is completely embedded in the PB1 coding region with a different reading frame [17] . In order to test its accuracy in gene finding, 2376 full and partial influenza segment sequences including group A, group B, and group C viruses, encoding 3177 annotated proteins, were run through VIGOR. VIGOR predicted 3178 ORFs encoded by these segments. Among these predicted protein sequences, 99% (3169/3178) ORFs completely agreed with the annotations in GenBank. Three predicted ORFs were partially correct and one ORF was incorrectly predicted ( Table 1) .

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