Author: Gupta, Neha; Richter, Robert; Robert, Stephen; Kong, Michele
Title: Viral Sepsis in Children Document date: 2018_9_18
ID: 050vjj6k_29
Snippet: In recent years, several viral-specific biomarkers have been identified. Many transcriptional signatures have been designed to distinguish viral infections from bacterial infections as well as non-infectious conditions (126, 127) . Zaas et al. identified a 30-gene signature to discriminate symptomatic influenza Ainfected subjects from both healthy and bacterially-infected subjects (128) . In a recent study by Herberg et al., a 2-transcript RNA si.....
Document: In recent years, several viral-specific biomarkers have been identified. Many transcriptional signatures have been designed to distinguish viral infections from bacterial infections as well as non-infectious conditions (126, 127) . Zaas et al. identified a 30-gene signature to discriminate symptomatic influenza Ainfected subjects from both healthy and bacterially-infected subjects (128) . In a recent study by Herberg et al., a 2-transcript RNA signature [FAM89A and IFI44L) showed promising results in its ability to distinguish between bacterial and viral infections, demonstrating that the expression of IFI44L was increased in patients with viral infection, whereas expression of FAM89A was increased in patients with bacterial infection (118) . Another recent study identified a four-gene expression signature in whole blood to distinguish viral infections from other etiologies (129) . Human myxovirus resistance protein 1 (MxA) is an important intermediate product in the IFN-mediated antiviral response against a variety of viruses. Serum MxA levels are significantly higher in patients with viral infections compared to bacterial infections in pediatric population and thus may be an additionally useful biomarker to discriminate viral from bacterial illness (130) .
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