Author: Gupta, Neha; Richter, Robert; Robert, Stephen; Kong, Michele
Title: Viral Sepsis in Children Document date: 2018_9_18
ID: 050vjj6k_28
Snippet: Several serum biomarkers, including lactate, C-reactive protein (CRP), and procalcitonin (PCT), are used to guide management in sepsis and are an important part of early goal directed therapy (119) . PCT is more commonly used in the ICU setting for early determination of the likelihood of a bacterial etiology for sepsis and to guide antimicrobial duration (120, 121) . Serum PCT has been shown to be elevated in bacterial infections and is superior.....
Document: Several serum biomarkers, including lactate, C-reactive protein (CRP), and procalcitonin (PCT), are used to guide management in sepsis and are an important part of early goal directed therapy (119) . PCT is more commonly used in the ICU setting for early determination of the likelihood of a bacterial etiology for sepsis and to guide antimicrobial duration (120, 121) . Serum PCT has been shown to be elevated in bacterial infections and is superior to CRP in assessing the severity and course of the disease (122) . However, the mean sensitivity of PCT as a biomarker of sepsis remains low at 77%, with a specificity of 79% (123, 124) . Unfortunately, in general, these biomarkers are non-specific in distinguishing bacterial vs. viral infection (125) .
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