Selected article for: "reading frame and upstream codon"
Author: Wang, Shiliang; Sundaram, Jaideep P; Spiro, David
Title: VIGOR, an annotation program for small viral genomes
  • Document date: 2010_9_7
    • ID: 0lbxvudt_11
    Snippet: The first transcript of coronavirus genomes and SARS coronavirus genomes encodes two polyproteins because of ribosomal slippage during translation [6] . The first polyprotein (orf1a) is translated from the sequence with start and stop codons, and normal translation, while the synthesis of the second polyprotein (orf1ab) is dependent on a -1 nucleotide ribosomal frameshift induced by a "slippery" sequence of the type "UUUAAAC" upstream of the orf1.....
    Document: The first transcript of coronavirus genomes and SARS coronavirus genomes encodes two polyproteins because of ribosomal slippage during translation [6] . The first polyprotein (orf1a) is translated from the sequence with start and stop codons, and normal translation, while the synthesis of the second polyprotein (orf1ab) is dependent on a -1 nucleotide ribosomal frameshift induced by a "slippery" sequence of the type "UUUAAAC" upstream of the orf1a stop codon [7] . VIGOR examines the region upstream of the orf1a stop codon to map out precisely the "UUUAAAC" string. It then shifts back the reading frame by -1 nucleotide (from AAC to AAA) within the slippery sequence, and the -1 frame is extended to generate the coding sequence for the translation of orf1ab.

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