Author: Kolodziejek, Jolanta; Seidel, Bernhard; Jungbauer, Christof; Dimmel, Katharina; Kolodziejek, Michael; Rudolf, Ivo; Hubálek, Zdenek; Allerberger, Franz; Nowotny, Norbert
Title: West Nile Virus Positive Blood Donation and Subsequent Entomological Investigation, Austria, 2014 Document date: 2015_5_11
ID: 0vm2hhdr_54
Snippet: doi:10.1371/journal.pone.0126381.g001 position 249 of the NS3 gene responsible for higher strain virulence [16] was, however, not identified in any of the Austrian strains. At this position histidine was determined. Furthermore, while in both the original human plasma-and mosquito-derived sequences N-glycosylation motif NYS at positions 154-156 of the E protein were identified [13] , [14] , it was no longer found in the sequences obtained from SM.....
Document: doi:10.1371/journal.pone.0126381.g001 position 249 of the NS3 gene responsible for higher strain virulence [16] was, however, not identified in any of the Austrian strains. At this position histidine was determined. Furthermore, while in both the original human plasma-and mosquito-derived sequences N-glycosylation motif NYS at positions 154-156 of the E protein were identified [13] , [14] , it was no longer found in the sequences obtained from SMB 1 , SPF i.c. and SPF i.p. passages of the plasma isolate. As mentioned above, at position 154, lysine instead of asparagine was identified. Experimental infection of adult SPF mice with mouse brain homogenate SMB 1 resulted in 100% mortality.
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