Author: Gupta, Neha; Richter, Robert; Robert, Stephen; Kong, Michele
Title: Viral Sepsis in Children Document date: 2018_9_18
ID: 050vjj6k_21
Snippet: Similar to bacterial coinfections, critically ill children can be simultaneously infected by multiple viruses. The course of illness in patients with viral coinfections depend on virusvirus interaction. Various mechanisms for disease virulence in viral coinfections have been proposed, including viral gene interactions, immunologic interactions and alteration in host environment (100). Even though the clinical significance such interactions is unk.....
Document: Similar to bacterial coinfections, critically ill children can be simultaneously infected by multiple viruses. The course of illness in patients with viral coinfections depend on virusvirus interaction. Various mechanisms for disease virulence in viral coinfections have been proposed, including viral gene interactions, immunologic interactions and alteration in host environment (100). Even though the clinical significance such interactions is unknown, a study by Rhedin et al. reported increased risk of severe respiratory disease in patients with viral coinfections compared to those with single viral infections (101).
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