Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_26
Snippet: To evaluate the function of bat tetherin proteins, we analysed tetherin from two Australian bats, the fruit bat P. alecto and the vesper bat M. macropus. The coding sequences of the P. alecto tetherin isoforms A, B, and C, and M. macropus tetherin A and B, were cloned into mammalian expression plasmids. While numerous vesper bat tetherins were identified in this study, M. macropus tetherin A and tetherin B were selected for further analysis as te.....
Document: To evaluate the function of bat tetherin proteins, we analysed tetherin from two Australian bats, the fruit bat P. alecto and the vesper bat M. macropus. The coding sequences of the P. alecto tetherin isoforms A, B, and C, and M. macropus tetherin A and B, were cloned into mammalian expression plasmids. While numerous vesper bat tetherins were identified in this study, M. macropus tetherin A and tetherin B were selected for further analysis as tetherin A is a homolog of human l-tetherin and tetherin B was the most structurally unique, since it possessed a large deletion within the extracellular coiled-coil domain compared to tetherin A ( Figure 4B ).
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