Virome Profiling of Bats from Myanmar by Metagenomic Analysis of Tissue Samples Reveals More Novel Mammalian Viruses

He, Biao; Li, Zuosheng; Yang, Fanli; Zheng, Junfeng; Feng, Ye; Guo, Huancheng; Li, Yingying; Wang, Yiyin; Su, Nan; Zhang, Fuqiang; Fan, Quanshui; Tu, Changchun

The members of the family Adenoviridae infect a wide range of vertebrates including mammals, birds, amphibians, reptiles and fish, and cause a variety of diseases [51, 52] . In this study, only one contig showing identity with genus Mastadenovirus was found in group WO (Table 3) . Further screening of all lungs and guts of bat samples by PCR of a partial hexon gene sequence of mammalian adenovirus (767 nt) confirmed that this sequence existed in guts of R. ferrumequinum of group WO but none of the other 3 groups. Sequence and phylogenetic analysis showed that this bat adenovirus, given the name WOR1 (accession number: JX863729), is divergent from current mammalian adenoviruses with 40-55% aa identity and with only 55% and 53% aa identities with bat adenovirus TJM strain from Tianjin, China, and bat adenovirus 2 strain PPV1 from Germany respectively ( Figure 5 ) [22, 53] . This indicates that bat adenovirus WOR1 is a new mammalian adenovirus.