Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_4
Snippet: Tetherin is common to all mammals, and orthologs which share structural and functional, but not sequence similarity, exist in other vertebrates (23) . Most mammals carry only a single tetherin gene; however gene duplication has been observed in sheep, cows, opossums and wallabies (23, 35) . Furthermore, human tetherin is expressed in two alternative isoforms (24) , the long (l-tetherin) and short (s-tetherin) isoforms, which differ through the tr.....
Document: Tetherin is common to all mammals, and orthologs which share structural and functional, but not sequence similarity, exist in other vertebrates (23) . Most mammals carry only a single tetherin gene; however gene duplication has been observed in sheep, cows, opossums and wallabies (23, 35) . Furthermore, human tetherin is expressed in two alternative isoforms (24) , the long (l-tetherin) and short (s-tetherin) isoforms, which differ through the truncation of 12 amino acid residues at the N-terminus of l-tetherin.
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