Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_5
Snippet: Computational predictions also indicate two additional isoforms, X1 and X2, with an internal, rather than N-terminal difference in amino acid sequences, may also be expressed in fruit bats i.e. megabats of the suborder Yinpterochiroptera, genus Pteropus (19) . The predicted isoform X1 is homologous to human l-tetherin, and the X2 isoform is a splice variant which contains a 7 AA exclusion within the extracellular coiled-coil domain relative to is.....
Document: Computational predictions also indicate two additional isoforms, X1 and X2, with an internal, rather than N-terminal difference in amino acid sequences, may also be expressed in fruit bats i.e. megabats of the suborder Yinpterochiroptera, genus Pteropus (19) . The predicted isoform X1 is homologous to human l-tetherin, and the X2 isoform is a splice variant which contains a 7 AA exclusion within the extracellular coiled-coil domain relative to isoform X1. A recent analysis of tetherin in fruit bats has identified that, similar to other mammals, bat tetherin is a functional restriction factor capable of inhibiting the release of the bat-hosted Nipah virus, as well as virus-like particles (VLPs) produced from the Ebola virus and the human immunodeficiency virus (19) .
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