Author: Chang, Chia Lin; Semyonov, Jenia; Cheng, Po Jen; Huang, Shang Yu; Park, Jae Il; Tsai, Huai-Jen; Lin, Cheng-Yung; Grützner, Frank; Soong, Yung Kuei; Cai, James J.; Hsu, Sheau Yu Teddy
Title: Widespread Divergence of the CEACAM/PSG Genes in Vertebrates and Humans Suggests Sensitivity to Selection Document date: 2013_4_16
ID: 1jogs44p_30
Snippet: Taken together, these in silico analyses suggested that CEA-CAM-like gene found in basal taxonomy are orthologous to human CEACAM genes, but have undergone extensive local duplication or gene loss, resembling the repeated expansion of CEACAM/PSG genes in select therian mammals. In support of this observation, phylogenetic trees built with Neighbor-Joining and Maximum Likelihood methods indicated that five of the eight zebrafish CEACAMs on chromos.....
Document: Taken together, these in silico analyses suggested that CEA-CAM-like gene found in basal taxonomy are orthologous to human CEACAM genes, but have undergone extensive local duplication or gene loss, resembling the repeated expansion of CEACAM/PSG genes in select therian mammals. In support of this observation, phylogenetic trees built with Neighbor-Joining and Maximum Likelihood methods indicated that five of the eight zebrafish CEACAMs on chromosome 16 (DreCEACAMI-V) form a sub-branch in which no homologs from other species are present, indicating that lineage-specific expansion could account for the large number of CEACAM homologs found in select fish species (Figs. 2c and 3c ).
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