Widespread Divergence of the CEACAM/PSG Genes in Vertebrates and Humans Suggests Sensitivity to Selection

Chang, Chia Lin; Semyonov, Jenia; Cheng, Po Jen; Huang, Shang Yu; Park, Jae Il; Tsai, Huai-Jen; Lin, Cheng-Yung; Grützner, Frank; Soong, Yung Kuei; Cai, James J.; Hsu, Sheau Yu Teddy

File S1 The supporting information file contains a total of six supplemental figures (Figures S1-S6 ) and six supplemental tables (Tables S1-S6). Figure S1 . Alignment of CEACAM homologs. Figure S2 . Identification of the immunoreceptor tyrosine-based activation motif (ITAM) in the cytoplasmic domain of zebrafish CEACAMs. Figure S3 . Schematic representation of a putative evolutionary trajectory of CEACAM genes in teleosts and tetrapods. Figure S4 . Schematic representation of CNVs found at the CEACAM/PSG locus based on studies using low-density probes (International HapMap Project webserver). Figure S5 . Distribution of allele frequencies of select nonsynonymous SNPs of PSG4, CEACAM1, CEACAM18, and CEACAM21 in HGDP-CEPH world populations. Figure S6 .