Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection Document date: 2020_1_20
ID: 0zr2e8lh_17
Snippet: In addition to the direct modulation of the ER structure, ZIKV also induces the formation of viroplasm-like structures, which is incidentally the first reported observation of such structure in flavivirus infection [41] . Contrary to other ZIKV-induced structures, viroplasms are cytoplasmic inclusion of viral replication components and various relevant host factors associated with virus replication that are formed through reorganization of cell m.....
Document: In addition to the direct modulation of the ER structure, ZIKV also induces the formation of viroplasm-like structures, which is incidentally the first reported observation of such structure in flavivirus infection [41] . Contrary to other ZIKV-induced structures, viroplasms are cytoplasmic inclusion of viral replication components and various relevant host factors associated with virus replication that are formed through reorganization of cell membrane or cytoskeletal elements [42] . These structures are significantly larger than VPs and can measure up to 500 nm in diameter [41] . Viroplasms are primarily located in the perinuclear region and in close proximity to the ER, mitochondria, and microtubules to facilitate viral genome replication [41] .
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