Selected article for: "bind protein and ER stress"
Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection
  • Document date: 2020_1_20
    • ID: 0zr2e8lh_22
    Snippet: Under normal conditions, glucose regulated protein 78 (GRP78), one of the ER molecular chaperones, binds to ER stress sensor transmembrane proteins: protein kinase RNA-activated (PKR)-like ER resident kinase (PERK), activating transcription factor 6 (ATF6), and inositolrequiring enzyme 1 (IRE1). In the presence of misfolded or unfolded protein, GRP78 will bind to exposed hydrophobic residues of these proteins to induce proper protein folding [45,.....
    Document: Under normal conditions, glucose regulated protein 78 (GRP78), one of the ER molecular chaperones, binds to ER stress sensor transmembrane proteins: protein kinase RNA-activated (PKR)-like ER resident kinase (PERK), activating transcription factor 6 (ATF6), and inositolrequiring enzyme 1 (IRE1). In the presence of misfolded or unfolded protein, GRP78 will bind to exposed hydrophobic residues of these proteins to induce proper protein folding [45, 46] . Accordingly, during ER stress, the accumulation of misfolded or unfolded proteins saturates the free pool of GRP78 and titrates the bound GRP78 away from the stress sensors leading to activation of respective sensor's molecular pathways [45] .

    Search related documents:
    Co phrase search for related documents
    • ER molecular chaperone and molecular chaperone: 1, 2, 3, 4, 5
    • ER resident kinase and ER stress: 1, 2
    • ER resident kinase and PERK ER resident kinase: 1
    • ER resident kinase and protein kinase: 1
    • ER resident kinase and resident kinase: 1, 2
    • ER stress and molecular chaperone: 1, 2, 3
    • ER stress and molecular pathway: 1
    • ER stress and PERK ER resident kinase: 1
    • ER stress and proper protein: 1, 2, 3
    • ER stress and protein kinase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • ER stress and resident kinase: 1, 2
    • ER stress sensor and protein kinase: 1, 2
    • hydrophobic residue and protein hydrophobic residue: 1, 2, 3, 4
    • hydrophobic residue and protein kinase: 1
    • molecular chaperone and protein kinase: 1
    • molecular pathway and protein kinase: 1, 2, 3, 4, 5
    • normal condition and protein kinase: 1
    • PERK ER resident kinase and protein kinase: 1
    • PERK ER resident kinase and resident kinase: 1