Selected article for: "sensor protein and transmembrane stress sensor"
Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection
  • Document date: 2020_1_20
    • ID: 0zr2e8lh_22
    Snippet: Under normal conditions, glucose regulated protein 78 (GRP78), one of the ER molecular chaperones, binds to ER stress sensor transmembrane proteins: protein kinase RNA-activated (PKR)-like ER resident kinase (PERK), activating transcription factor 6 (ATF6), and inositolrequiring enzyme 1 (IRE1). In the presence of misfolded or unfolded protein, GRP78 will bind to exposed hydrophobic residues of these proteins to induce proper protein folding [45,.....
    Document: Under normal conditions, glucose regulated protein 78 (GRP78), one of the ER molecular chaperones, binds to ER stress sensor transmembrane proteins: protein kinase RNA-activated (PKR)-like ER resident kinase (PERK), activating transcription factor 6 (ATF6), and inositolrequiring enzyme 1 (IRE1). In the presence of misfolded or unfolded protein, GRP78 will bind to exposed hydrophobic residues of these proteins to induce proper protein folding [45, 46] . Accordingly, during ER stress, the accumulation of misfolded or unfolded proteins saturates the free pool of GRP78 and titrates the bound GRP78 away from the stress sensors leading to activation of respective sensor's molecular pathways [45] .

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