Selected article for: "CHOP expression and ER stress"
Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection
  • Document date: 2020_1_20
    • ID: 0zr2e8lh_32
    Snippet: ZIKV infection has been shown to promote XBP1 splicing and XBP1s translocation into the nucleus, leading to elevated expression of XBP1 downstream effectors such as ER degradation-enhancing α-mannosidase-like 1 (EDEM-1) and CHOP, indicating the activation of the IRE1 arm of the UPR [48] . EDEM-1 is an enzyme involved in the ERAD process that recognizes and facilitates retrotranslocation of misfolded proteins to the cytosol for subsequent proteas.....
    Document: ZIKV infection has been shown to promote XBP1 splicing and XBP1s translocation into the nucleus, leading to elevated expression of XBP1 downstream effectors such as ER degradation-enhancing α-mannosidase-like 1 (EDEM-1) and CHOP, indicating the activation of the IRE1 arm of the UPR [48] . EDEM-1 is an enzyme involved in the ERAD process that recognizes and facilitates retrotranslocation of misfolded proteins to the cytosol for subsequent proteasomal degradation and thus, alleviating stress damage [65] . Instances of aggravated ER stress were also demonstrated in ZIKV-infected cells, which lead to elevated expression of CHOP protein and initiation of ERstress-induced apoptosis [49] . Pharmacological intervention using IRE1 inhibitor, 4μ8C, prevented microcephaly and impaired ZIKV replication in mouse fetal brains [49] . Modulation of IRE1-ASK1 pathway during ZIKV infection is still unclear.

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