Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_31
Snippet: Taking the influence of RV on p53 intracellular distribution into account, different stress stimuli were applied and subjected to immunofluorescence analysis, such that it could be determined whether a co-activation mechanism between these two proteins exists. Figure 6F shows that both heat shock and incubation with 0.003% hydrogen peroxide induced a shift of Cyp40 and p53 to the nucleus. The application of both camptothecin (CPT) and cycloheximi.....
Document: Taking the influence of RV on p53 intracellular distribution into account, different stress stimuli were applied and subjected to immunofluorescence analysis, such that it could be determined whether a co-activation mechanism between these two proteins exists. Figure 6F shows that both heat shock and incubation with 0.003% hydrogen peroxide induced a shift of Cyp40 and p53 to the nucleus. The application of both camptothecin (CPT) and cycloheximide (CHX) reflects that nuclear localization of p53 and Cyp40 is not necessarily an interdependent event. CPT induces a significant portion of p53 in the nucleus, but Cyp40 remains unchanged. The application of CHX results in the opposite situation; Cyp40 is completely redistributed to the nucleus while p53 is left unaffected.
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